| Pair Name | Chlorogenic acid, Methotrexate | ||
| Phytochemical Name | Chlorogenic acid (PubChem CID: 1794427 ) | ||
| Anticancer drug Name | Methotrexate (PubChem CID: 126941 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Drug Name | Methotrexate |
| Adverse Reactions | Acne, stomatitis, mouth and lip ulcers. This was inferred hot nature anticancer drug. |
| Recommendations | Cold: Paeonia suffruticosa; Scutellaria baicalensis; Centella asiatica; Lonicera japonica |
| Reference | ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899. ref_link |
| Pair Name | Chlorogenic acid, Methotrexate | |||
| Disease Info | [ICD-11: 2B33.4] | Leukemia | Investigative | |
| Biological Phenomena | Induction-->Apoptosis | |||
| Gene Regulation | Up-regulation | Expression | BAX | hsa581 |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP9 | hsa842 | |
| Down-regulation | Expression | COX2 | hsa4513 | |
| Down-regulation | Expression | GPT | hsa2875 | |
| Down-regulation | Expression | LDHA | hsa3939 | |
| Down-regulation | Expression | NOS2 | hsa4843 | |
| In Vivo Model | 6-8 weeks old Male Wistar rats (150-200 g) were use in this study. | |||
| Result | These results imply that CGA has perfective effect against MTX-induced liver injury. Hence CGA supplementation might be helpful in abrogation of MTX toxicity. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Protective effect of Chlorogenic acid against methotrexate induced oxidative stress, inflammation and apoptosis in rat liver: An experimental approach. Chem Biol Interact. 2017 Jun 25;272:80-91. doi: 10.1016/j.cbi.2017.05.002. | Click |
